Note: You will not be able to register for this workshop through the ACoP registration tool.  Please visit http://www.pharsight.com/training/course_display_new.php?details_id=66  to register. 

Date: Sunday, October 4, 2009, 8:30am to 4:30pm

Registration fee: Commercial ($350), Academia ($150), Student (free - limited to 10 places)

Maximum class size: 50

Sponsor: Pharsight Corporation

Instructor: Daniel Weiner

Workshop summary:

This hands-on workshop will give participants an opportunity to become familiar with Phoenix NLME, a next generation nonlinear mixed effects modeling product. Instruction will be given on basic data management and exploratory graphical and tabular data analysis methods, as well as model building, comparison and evaluation of methods for nonlinear mixed effects modeling. Using the integral Phoenix Connect function, attendees will be able to include NONMEM, SAS and S-Plus scripts in graphical workflows along with Phoenix NLME. At the conclusion of the workshop users will be given a license to continue to use Phoenix for 60 days without charge.

Schedule:

Overview of Basic Phoenix Platform Functionality

• Importing data
• Basic data management
• Graphical summaries including lattice plots
• Creating workflows

Population PK/PD Modeling

• Building a base model via model libraries, the graphical model builder (Phoenix writes the corresponding model code automatically) and via the Phoenix modeling language
• Strategies for covariate selection (shotgun approach, user specified scenarios and forward selection/backward elimination)
• Use of Phoenix Model Comparison tool to aid selection of the best model
• Interpretation of standard model output including diagnostic plots (including CWRES and other diagnostic plots) and model fitting summaries
• Bootstrap and posterior predictive checks

Using Phoenix Connect

• Using S-Plus and SAS to pre- and post-process data files and model results
• Using NONMEM control files in Phoenix workflows